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The proper slope of a ladder used in construction is based on the safest angle to ensure stability and ease of use. The ratio of every 4 feet vertically up corresponds to 1 foot horizontally out from the wall creates a 75-degree angle, which is widely considered to be both safe and effective. This particular angle provides a good balance between stability and reach, minimizing the risk of the ladder tipping backward while allowing for safe ascent and descent.

A slope of 4:1 is also backed by safety standards and regulations, making it essential for compliance in construction practices. This ensures that the ladder is positioned correctly to support the weight of the user and any additional materials they may be carrying, preventing accidents that could occur if the ladder were too steep or positioned improperly.

In contrast, the other slopes provided do not align with the recommended practices for ladder use in construction, which emphasize the necessity of a safe and secure work environment.